MagaPhase® Product Line
The CORTEX BIOCHEM MagaPhase® technology utilizes a unique encapsulation process, whereby ultra-pure paramagnetic iron oxide (Fe3O4) is suspended and uniformly entrapped in a variety of polymer supports such as polysaccharides, acrylic polymers, and co-polymers. This method produces a reliable, consistent, and low-cost super paramagnetic support, which has been used in a variety of successful commercial manual and automated magnetic assays. MagaPhase® particles are "paramagnetic"; once the magnetic field has been removed, MagaPhase® particles do not retain residual magnetism. Magnetic particles have been found useful in many applications including Immunoassays, Cell Separation, and DNA isolation, RNA purification and PCR dye removal. In large-scale purification procedures MagaPhase® products can replace non-magnetizable particles. This simplifies processing and increases purified product recovery to its maximum potential by reducing cumbersome manipulation steps.

MagaZorb® DNA Isolation Kits:
Using one simple protocol, high yield of purified genomic DNA can be isolated from various biological sources including whole blood, buffy coat, leukocytes, tissues and cultured cells. MagaZorb® DNA Isolation is suitable for use with fresh or frozen whole blood as well as blood which has been treated with commonly used anticoagulants such as citrate, heparin or EDTA. Typically, 5 - 12 µg of genomic DNA is recovered from 200 µl of whole blood. The technique does not require an organic solvent and is well suited to the processing of multiple samples. This proprietary technology eliminates the need for centrifugation, vacuum filtration or column separation, thereby increasing sample throughput and improved reproducibility. DNA purified by MagaZorb® DNA is ready for downstream applications such as PCR, sequencing or blotting procedures.

MagaZorb® RNA lsolation Kits
The MagaZorb® Nucleic Acid Isolation System is an innovative magnetic separation based technology with timesaving and simple-to-use features. This unique product utilizes Cortex Biochem’s proprietary magnetic particles (MagaZorb® Reagent), designed to specifically and exclusively interact with nucleic acids. Due to the high affinity and specificity of MagaZorb® Reagent for nucleic acids, this interaction, unlike silica-based technologies, is independent of an organic solvent or a chaotropic agent. The high capacity of the MagaZorb® Reagent allows purification of very high yields of PCR quality nucleic acids. The MagaZorb® technology utilizes a simple and rapid protocol; without any need for centrifugation, column separation, vacuum, or filtration. The MagaZorb® Nucleic Acid Isolation System is readily and truly adaptable to automation.
The MagaZorb® RNA Mini-Prep Kit is a magnetic separation-based technology suitable for manual, semi-automated, and automated system applications. Using a simple protocol, similar to MagaZorb® DNA Isolation, high yields of purified RNA can be isolated from whole blood, as well as blood that has been treated with commonly used anticoagulants such as citrate, heparin, or EDTA. Typically, >3 µg of total RNA is recovered from 1 ml of whole blood. High Yields of Purified RNA can also be isolated from other sources, such as buffy coat (white blood cells), cultured cells, tissues, stool, serum, plasma, and other biological fluids. The MagaZorb® RNA Isolation System is favorable from many key vantage points. It is one of the first industry offerings of an RNA purification kit that does not require the preparation of ancillary reagents. More importantly, it does not use organic solvents or hazardous ß-mercaptoethanol, eliminating costly hazardous waste storage and disposal. The MagaZorb® RNA Isolation Kit breaks the barriers of procedure simplicity. Using one single wash buffer and a simple protocol, MagaZorb® RNA turns a complex of tedious tasks into shear simplicity!

MagaZorb® Total Nucleic Acid Isolation Kits
The MagaZorb® Total Nucleic Acid Isolation Kit is a magnetic based technology suitable for manual, semi-auomated and automated system applications. Existing Total Nucleic Acid purification procedures are tedious, time consuming, laborious, and often involve hazardous materials such as organic solvents or ß-mercaptoethanol that require preparations prior to the isolation process. As molecular diagnostics tests are evolving into routine practice in research and clinical laboratories, the need for a fast, reliable, and cost effective way to purify nucleic acids from a wide variety of sample types becomes a reality. The MagaZorb® Total Nucleic Acid Isolation System is designed to be the solution, offering high quality, high yield and high purity total nucleic acids combined with speed, ease-of-use, and reliability. The purified total nucleic acids (RNA and/or DNA) are ready for downstream applications such as PCR.